Why the study?
Does co-administration of terfenadine and ketoconazole cause QT prolongation and Torsades de Pointes?
Population
22-year-old healthy female (n=1)
Design
Case_report
Follow-up
5 days
Authors
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Raises caution for terfenadine-ketoconazole co-use; hypothesis-generating and should not yet change practice.
Does co-administration of terfenadine and ketoconazole cause QT prolongation and Torsades de Pointes?
Co-administration of terfenadine and ketoconazole can lead to severe adverse cardiac events, specifically QT prolongation and symptomatic Torsades de Pointes.
ZlMMERMANN et al. (1992) studied this question.
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