Key result
Concurrent use of terfenadine and ketoconazole triggers life-threatening torsades de pointes due to inhibition of terfenadine metabolism.
Why the study?
Does concurrent use of terfenadine and ketoconazole increase the risk of torsades de pointes?
Does concurrent use of terfenadine and ketoconazole increase the risk of torsades de pointes?
No takes yet. Share an insight, caveat, or question.
Highlights the critical importance of recognizing drug-drug interactions, specifically the inhibition of oxidative metabolism, in preventing life-threatening arrhythmias like torsades de pointes.
Carl C. Peck (1993) conducted an editorial in Torsades de pointes. Concurrent terfenadine and ketoconazole was evaluated. Concurrent use of terfenadine and ketoconazole triggers life-threatening torsades de pointes due to inhibition of terfenadine metabolism.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: