Key result
Concurrent use of terfenadine and ketoconazole was identified as a trigger for life-threatening torsades de pointes due to inhibition of terfenadine metabolism.
Population
Otherwise healthy young woman and patients in the FDA spontaneous reporting system
Design
Editorial
Authors
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Highlights the critical importance of recognizing drug-drug interactions, specifically the historical identification of torsades de pointes risk with concurrent terfenadine and ketoconazole use.
Case Report
Highlights the critical importance of recognizing drug-drug interactions, specifically the historical identification of torsades de pointes risk with concurrent terfenadine and ketoconazole use.
C. C. Peck (1993) conducted a case report in Torsades de pointes. Concurrent terfenadine and ketoconazole was evaluated on Torsades de pointes. Concurrent use of terfenadine and ketoconazole was identified as a trigger for life-threatening torsades de pointes due to inhibition of terfenadine metabolism.
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