Key result
Combination therapy with terfenadine and ketoconazole led to the development of Torsade de Pointes in a single reported case.
Why the study?
Does combination therapy of terfenadine and ketoconazole cause Torsade de pointes?
Population
1 patient receiving combination therapy of terfenadine and ketoconazole
Design
Case_report
Authors
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Reports of TdP with terfenadine or astemizole plus antifungals warrant prescribing caution; leaves open the population-level risk magnitude.
Case Report (n=1)
Does combination therapy of terfenadine and ketoconazole cause Torsade de pointes?
Highlights the risk of Torsade de pointes when combining the antihistamine terfenadine with the antifungal ketoconazole.
Oh et al. (1998) conducted a case report in Torsade de Pointes (n=1). Terfenadine and ketoconazole combination therapy was evaluated on Torsade de Pointes. Combination therapy with terfenadine and ketoconazole led to the development of Torsade de Pointes in a single reported case.
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