Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program

Bradley A. Maron; Edward Hess; Thomas M. Maddox; Alexander R. Opotowsky; Ryan J. Tedford; Tim Lahm; Karen E. Joynt; Daniel J. Kass; Thomas Stephens; Maggie A. Stanislawski; Erik R. Swenson; Ronald H. Goldstein; Jane A. Leopold; Roham T. Zamanian; Jean Elwing; Mary E. Plomondon; Gary K. Grunwald; Anna E. Barón; John S. Rumsfeld; Gaurav Choudhary

doi:10.1161/circulationaha.115.020207

Why the study?

Is borderline pulmonary hypertension associated with increased mortality and hospitalization in a Veterans Affairs patient cohort?

Key Points

To assess the clinical impact of borderline pulmonary hypertension and evaluate the relationship between mean pulmonary arterial pressure levels, mortality, and hospitalizations.
Conducted a large patient cohort analysis utilizing data from the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program.
Tracked clinical outcomes, specifically all-cause mortality and hospital admissions, across varying levels of mean pulmonary arterial pressure (mPAP).
Demonstrated a continuum of clinical risk directly corresponding to increasing levels of mean pulmonary arterial pressure (mPAP).
Borderline pulmonary hypertension was significantly associated with elevated rates of both mortality and hospitalization compared to normal pressures.

Structured PICO

Is borderline pulmonary hypertension associated with increased mortality and hospitalization in a Veterans Affairs patient cohort?

P

Population

Patients in the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program assessed for mean pulmonary arterial pressure (mPAP)

I

Intervention

Borderline pulmonary hypertension (exposure)

C

Comparator

Patients without borderline pulmonary hypertension / lower mPAP levels

O

Outcome

Mortality and hospitalizationhard clinical

Borderline pulmonary hypertension is associated with increased mortality and hospitalization, indicating a continuum of risk based on mPAP levels.

Limitations

Generalizability to other populations needs to be tested

Implication

May inform risk stratification; leaves open whether intervention improves outcomes in borderline PH.

Abstract

These data illustrate a continuum of risk according to mPAP level and that borderline PH is associated with increased mortality and hospitalization. Future investigations are needed to test the generalizability of our findings to other populations and study the effect of treatment on outcome in borderline PH.

Discussion

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Cite This Study

Maron et al. (2016) studied this question.

synapsesocial.com/papers/69d5720b75589c71d767e422 https://doi.org/10.1161/circulationaha.115.020207

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Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program

Key Points

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program

Key Points

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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