Key result
Exercise pulmonary hypertension in borderline resting mPAP is linked to reduced peak oxygen uptake.
Why the study?
The pathophysiological mechanisms underlying exertional intolerance in patients with borderline resting mean pulmonary arterial pressure remain incompletely characterized.
Population
312 patients with resting mPAP <25 mmHg and PAWP ≤15 mmHg undergoing RHC and invasive cardiopulmonary exercise testing
Comparison
Exercise pulmonary hypertension vs resting precapillary pulmonary hypertension vs normal hemodynamics
Design
Observational study with invasive cardiopulmonary exercise testing
Authors
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Exercise hemodynamics may identify functional limitation in borderline mPAP; leaves open whether routine assessment alters management or outcomes.
Observational (n=312)
p-value: p=<0.01
Exercise pulmonary hypertension is common in patients with borderline resting mPAP and causes exercise intolerance similar to resting pulmonary hypertension, highlighting the value of exercise hemodynamics.
Oliveira et al. (2017) conducted an observational in Borderline resting pulmonary arterial pressure (n=312). Exercise pulmonary hypertension (ePH) vs. Normal hemodynamics (non-PH) was evaluated on Peak oxygen uptake (% predicted) (p=<0.01). Exercise pulmonary hypertension in patients with borderline resting mPAP significantly reduced peak oxygen uptake compared with normal hemodynamics across all mPAP epochs (P<0.05 to P<0.001).
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