Key result
In patients with precapillary pulmonary hypertension, elevated pulmonary arterial compliance (≥3.0 ml/mm Hg) was associated with a 41% improvement in survival (HR 0.59; 95% CI 0.55-0.62; P<0.001).
Why the study?
Predictors of adverse outcome in pulmonary hypertension are well established, but data informing survival are lacking.
Is elevated pulmonary arterial compliance (PAC ≥3.0 ml/mm Hg) associated with improved survival in patients with pulmonary hypertension?
Cohort (n=37,744)
Yes
Is elevated pulmonary arterial compliance (PAC ≥3.0 ml/mm Hg) associated with improved survival in patients with pulmonary hypertension?
Hazard Ratio: 0.59 (95% CI 0.55–0.62)
p-value: p=<0.001
Elevated pulmonary arterial compliance (≥3.0 ml/mm Hg) is strongly associated with improved survival in patients with pulmonary hypertension, suggesting its potential as a therapeutic target.
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Supports PAC monitoring for risk stratification in pulmonary hypertension; hypothesis-generating for therapeutic targeting, pending prospective trials.
Wang et al. (2023) conducted a cohort in Pulmonary hypertension (n=37,744). Pulmonary arterial compliance ≥3.0 ml/mm Hg vs. Pulmonary arterial compliance <3.0 ml/mm Hg was evaluated on Survival / All-cause mortality (HR 0.59, 95% CI 0.55-0.62, p=<0.001). In patients with precapillary pulmonary hypertension, elevated pulmonary arterial compliance (≥3.0 ml/mm Hg) was associated with a 41% improvement in survival (HR 0.59; 95% CI 0.55-0.62; P<0.001).
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