Key result
Higher pulmonary artery compliance was significantly associated with reduced mortality (HR 0.59 per 1-SD increase; 95% CI 0.56-0.63) and heart failure hospitalization.
Why the study?
While lower pulmonary artery compliance is linked to right heart failure and death in pulmonary arterial hypertension, its association with outcomes across broader cardiopulmonary comorbidities was unclear.
Is pulmonary artery compliance associated with mortality and heart failure hospitalization in patients undergoing right heart catheterization?
Cohort (n=7,966)
No
Is pulmonary artery compliance associated with mortality and heart failure hospitalization in patients undergoing right heart catheterization?
Hazard Ratio: 0.59 (95% CI 0.56–0.63)
Lower pulmonary artery compliance is associated with increased mortality and heart failure hospitalization across a broad spectrum of cardiopulmonary disease, irrespective of the presence of pulmonary hypertension.
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PAC-outcome links in mixed cardiopulmonary disease remain hypothesis-generating; prospective studies needed before prognostic use.
Mounsey et al. (2025) conducted a cohort in Patients undergoing clinically indicated right heart catheterization (n=7,966). Pulmonary artery compliance (PAC) vs. Lower PAC was evaluated on Mortality (HR 0.59, 95% CI 0.56, 0.63). Higher pulmonary artery compliance was significantly associated with reduced mortality (HR 0.59 per 1-SD increase; 95% CI 0.56-0.63) and heart failure hospitalization.
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