Key result
Higher pulmonary arterial capacitance is significantly associated with a reduced risk of cardiac death and worsening heart failure in patients with pulmonary hypertension due to left heart disease (HR 0.556).
Why the study?
Does pulmonary arterial capacitance predict cardiac events in patients with pulmonary hypertension due to left heart disease?
Cohort (n=252)
No
Does pulmonary arterial capacitance predict cardiac events in patients with pulmonary hypertension due to left heart disease?
Hazard Ratio: 0.556 (95% CI 0.424–0.73)
Absolute Event Rate: 66.7% vs 92.1%
p-value: p=<0.001
Pulmonary arterial capacitance is a significant independent predictor of cardiac events in patients with pulmonary hypertension due to left heart disease, outperforming pulmonary vascular resistance.
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Supports PAC for risk stratification in PH-LHD; hypothesis-generating and requires prospective validation before practice change.
Sugimoto et al. (2016) conducted a cohort in Pulmonary hypertension due to left heart disease (n=252). Pulmonary arterial capacitance vs. Higher pulmonary arterial capacitance was evaluated on Rehospitalization due to worsening heart failure and/or cardiac death (HR 0.556, 95% CI 0.424-0.730, p=<0.001). Higher pulmonary arterial capacitance is significantly associated with a reduced risk of cardiac death and worsening heart failure in patients with pulmonary hypertension due to left heart disease (HR 0.556).
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