Key result
Reduced pulmonary artery capacitance was an independent predictor of mortality in heart failure patients (HR 0.72 per 1 mL/mmHg increase; 95% CI 0.59-0.88; P=0.001).
Why the study?
Does reduced pulmonary artery capacitance predict mortality in patients with heart failure and reactive pulmonary hypertension?
Cohort (n=484)
Does reduced pulmonary artery capacitance predict mortality in patients with heart failure and reactive pulmonary hypertension?
Effect estimate: HR 0.72 per 1 mL/mmHg increase (95% CI 0.59-0.88)
p-value: p=0.001
Pulmonary artery capacitance is markedly reduced in reactive pulmonary hypertension and serves as a strong independent predictor of mortality in heart failure patients.
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Hypothesis-generating for pulmonary artery capacitance in heart failure prognostication; prospective studies needed before clinical adoption.
Dragu et al. (2014) conducted a cohort in Heart Failure and Reactive Pulmonary Hypertension (n=484). Pulmonary arterial capacitance (PAC) was evaluated on Mortality (HR 0.72 per 1 mL/mmHg increase, 95% CI 0.59-0.88, p=0.001). Reduced pulmonary artery capacitance was an independent predictor of mortality in heart failure patients (HR 0.72 per 1 mL/mmHg increase; 95% CI 0.59-0.88; P=0.001).
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