Key result
A decrease in pulmonary arterial capacitance over time was associated with increased mortality or lung transplantation in patients with group 1 pulmonary arterial hypertension (adjusted P=0.039).
Why the study?
Does longitudinal change in pulmonary arterial capacitance predict transplant-free survival in patients with group 1 pulmonary arterial hypertension?
Cohort (n=109)
No
Does longitudinal change in pulmonary arterial capacitance predict transplant-free survival in patients with group 1 pulmonary arterial hypertension?
p-value: p=0.039
A longitudinal decrease in pulmonary arterial capacitance is a significant predictor of mortality or lung transplantation in patients with group 1 PAH, supporting its potential use as a therapeutic target.
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Serial PAC monitoring may aid risk stratification in PAH; leaves open whether PAC changes are modifiable or improve outcomes.
Medrek et al. (2017) conducted a cohort in Pulmonary arterial hypertension (n=109). Change in pulmonary arterial capacitance (PAC) over time was evaluated on Composite outcome of death or lung transplantation (p=0.039). A decrease in pulmonary arterial capacitance over time was associated with increased mortality or lung transplantation in patients with group 1 pulmonary arterial hypertension (adjusted P=0.039).
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