Key result
Extreme coronary wall shear stress segments link to greater plaque progression and adverse remodeling vs intermediate.
Why the study?
The relationship between coronary artery wall shear stress and progression, transformation of atherosclerotic plaque, and arterial remodeling in coronary artery disease patients was not fully characterized.
Is abnormal coronary artery wall shear stress (low or high) associated with the progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease?
Cohort
Is abnormal coronary artery wall shear stress (low or high) associated with the progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease?
Both low and high coronary artery wall shear stress are associated with atherosclerotic plaque progression and transformation toward a more vulnerable phenotype.
Intermediate WSS may mark lower-risk segments; leaves open whether WSS modulation alters plaque outcomes.
Compared with intermediate-WSS coronary segments, low-WSS segments develop greater plaque and necrotic core progression and constrictive remodeling, and high-WSS segments develop greater necrotic core and calcium progression, regression of fibrous and fibrofatty tissue, and excessive expansive remodeling, suggestive of transformation to a more vulnerable phenotype. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576576.
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Samady et al. (2011) conducted a cohort in Coronary Artery Disease. Low and high coronary artery wall shear stress (WSS) vs. Intermediate-WSS coronary segments was evaluated on Progression and transformation of atherosclerotic plaque and arterial remodeling. Low and high coronary artery wall shear stress segments developed greater plaque progression, necrotic core expansion, and adverse remodeling compared with intermediate-WSS segments.
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