Incidence and clinical impact of major bleeding following left atrial appendage occlusion: insights from the Amplatzer Amulet Observational Post-Market Study

Adel Aminian; Ole De Backer; Jens Erik Nielsen‐Kudsk; Patrizio Mazzone; Sérgio Berti; Sven Fischer; Juha Lund; Matteo Montorfano; Simon Cheung Chi Lam; Xavier Freixa; Ryan Gage; Hans‐Christoph Diener; Boris Schmidt

doi:10.4244/eij-d-20-01309

October 1, 2021EuroInterventionOpen Access

Incidence and clinical impact of major bleeding following left atrial appendage occlusion: insights from the Amplatzer Amulet Observational Post-Market Study

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Key Points

To evaluate the incidence and clinical impact of major bleeding following left atrial appendage occlusion in high-risk patients.
Observed real-world patients undergoing left atrial appendage occlusion (LAAO) for high bleeding risk
Analyzed clinical outcomes, including mortality and stroke
Used ClinicalTrials.gov Identifier: NCT02447081 for reference.
Major bleeding occurred frequently in this high-risk population
No increase in stroke risk was observed following major bleeding incidents.

Population

Real-world patients at high bleeding risk undergoing LAAO

Design

Observational post-market study

Implication

Observational study reveals major bleeding increases mortality in high-risk patients post-left atrial appendage occlusion, suggesting a need for careful monitoring.

Abstract

In real-world patients at high bleeding risk, MB following LAAO was not uncommon and associated with a significant increase in mortality, without increasing the risk of stroke. ClinicalTrials.gov Identifier: NCT02447081. https://clinicaltrials.gov/ct2/show/NCT02447081.

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Cite This Study

Aminian et al. (2021) studied this question.

synapsesocial.com/papers/69d5724975589c71d767e6d2 https://doi.org/10.4244/eij-d-20-01309

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Incidence and clinical impact of major bleeding following left atrial appendage occlusion: insights from the Amplatzer Amulet Observational Post-Market Study

Key Points

Implication

Abstract

Discussion

Cite This Study

Incidence and clinical impact of major bleeding following left atrial appendage occlusion: insights from the Amplatzer Amulet Observational Post-Market Study

Key Points

Implication

Abstract

Discussion

Cite This Study

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