Why the study?
Does domperidone increase the risk of serious ventricular arrhythmia and sudden cardiac death?
Does domperidone increase the risk of serious ventricular arrhythmia and sudden cardiac death?
Current use of domperidone is associated with an increased risk of serious ventricular arrhythmia and sudden cardiac death.
Supports clinical caution with domperidone; leaves open causality pending randomized confirmation.
The increased risk of SVA/SCD for current domperidone users remained after adjustment for multiple covariates. The risk may vary among subgroups of exposed individuals.
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Johannes et al. (2010) studied this question.
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