December 8, 2015Cardiovascular ResearchOpen Access

Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion

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Structured PICO

Population

Preclinical atherosclerosis model (specifics not provided in abstract)

Intervention

Tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2

Comparator

Comparison between TIMP-1 and TIMP-2

Outcome

Atherosclerosis pathogenesis and monocyte/macrophage accumulation into plaquessurrogate

TIMP-2 provides greater protection against atherosclerosis than TIMP-1 by reducing MMP-14-dependent macrophage accumulation in plaques.

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Animal data suggest TIMP-2 as a potential atheroprotective target; leaves open translation to human therapy.

Gregoli et al. (2015) studied this question.

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