This review highlights autonomic dysfunction as a central mechanism in hypoglycemia-associated autonomic failure in diabetes.
May guide autonomic-targeted therapies for hypoglycemia unawareness; leaves open confirmation in prospective trials.
Asymptomatic hypoglycemia is a major problem in diabetes. Mechanisms involved in a patient's inability to sense low glucose levels are reviewed. Autonomic dysfunction is a key contributor. Mechanistic studies suggest interventions that may restore the normal autonomic response.
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Philip E. Cryer (2013) studied this question.
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