Key result
Lactate may promote hypoglycemia-associated autonomic failure by increasing hypothalamic GABA and suppressing glucose counterregulation.
Design
Review
Authors
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Highlights potential therapeutic targets to restore counterregulation in diabetes; leaves open whether lactate modulation alters clinical hypoglycemia risk.
Discusses the mechanism of hypoglycemia-associated autonomic failure in diabetes, highlighting the interplay of therapeutic insulin excess and compromised physiological defenses.
Arbeláez et al. (2013) conducted an editorial in Hypoglycemia-Associated Autonomic Failure (HAAF) in Diabetes. Lactate was evaluated. Lactate may act as a signaling molecule in the ventromedial hypothalamus to increase GABA levels and suppress glucose counterregulation, contributing to hypoglycemia-associated autonomic failure.
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