What question did this study set out to answer?

To determine whether maternal hyperoxygenation elicits pulmonary artery vasoreactivity in fetuses with hypoplastic left heart syndrome and whether testing predicts urgent neonatal intervention.

January 1, 2010Circulation Cardiovascular ImagingOpen Access

Vasoreactive Response to Maternal Hyperoxygenation in the Fetus With Hypoplastic Left Heart Syndrome

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Why the study?

Does maternal hyperoxygenation testing accurately identify fetuses with HLHS requiring urgent postnatal intervention?

Key Points

To determine whether maternal hyperoxygenation elicits pulmonary artery vasoreactivity in fetuses with hypoplastic left heart syndrome and whether testing predicts urgent neonatal intervention.
Evaluated fetal pulmonary artery vasoreactivity during maternal hyperoxygenation testing in fetuses diagnosed with hypoplastic left heart syndrome.
Assessed the diagnostic accuracy of maternal hyperoxygenation response for predicting the need for urgent postnatal intervention and candidate selection for fetal atrial septoplasty.
Pulmonary artery vasoreactivity to maternal hyperoxygenation occurs in fetuses affected by hypoplastic left heart syndrome.
Maternal hyperoxygenation testing accurately identifies fetuses requiring urgent postnatal interventions at birth and supports candidate selection for fetal atrial septoplasty.

Structured PICO

Does maternal hyperoxygenation testing accurately identify fetuses with HLHS requiring urgent postnatal intervention?

Population

Fetuses with hypoplastic left heart syndrome (HLHS)

Intervention

Maternal hyperoxygenation (MH) testing

Outcome

Identification of fetuses requiring urgent postnatal intervention at birth

Maternal hyperoxygenation testing is a useful diagnostic tool to identify fetuses with HLHS who will require urgent postnatal intervention or fetal atrial septoplasty.

Implication

Supports maternal hyperoxygenation testing for HLHS risk stratification; leaves open prospective validation before guiding fetal interventions.

Abstract

PA vasoreactivity to MH occurs in the fetus with HLHS. MH testing accurately identifies fetuses requiring urgent postnatal intervention at birth and may be used to select candidates for fetal atrial septoplasty.

Discussion

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Cite This Study

Szwast et al. (2010) studied this question.

synapsesocial.com/papers/69d688af49dce5ab9d88b469 https://doi.org/10.1161/circimaging.109.848432

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Implication

Supports maternal hyperoxygenation testing for HLHS risk stratification; leaves open prospective validation before guiding fetal interventions.

Vasoreactive Response to Maternal Hyperoxygenation in the Fetus With Hypoplastic Left Heart Syndrome

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Vasoreactive Response to Maternal Hyperoxygenation in the Fetus With Hypoplastic Left Heart Syndrome

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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