What question did this study set out to answer?

Summarize the molecular mechanisms governing anoikis and anoikis resistance across normal physiological conditions and human diseases, including cancer, cardiovascular disorders, and diabetes.

September 27, 2011The Journal of Pathology

Anoikis: an emerging hallmark in health and diseases

View Full Paper

Ask AI

Bookmark

Summarize the molecular mechanisms governing anoikis and anoikis resistance across normal physiological conditions and human diseases, including cancer, cardiovascular disorders, and diabetes.
Narrative review synthesizing molecular and cellular research on extracellular matrix detachment and integrin ligation signaling pathways.
Analysis of pathways mediating anchorage-independent growth, epithelial-mesenchymal transition, and resistance to detachment-induced apoptosis.
Anoikis acts as a vital physiological barrier preventing dysplastic colonization by initiating programmed cell death upon loss of correct integrin-extracellular matrix attachment.
Deregulation and acquisition of anoikis resistance via epithelial-mesenchymal transition and anchorage-independent growth critically facilitate metastatic dissemination, vascular abnormalities, and diabetic complications.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Narrative review details the molecular mechanisms of anoikis and anoikis resistance in human health and disease, highlighting critical therapeutic targets in metastasis, cardiovascular disease,...

Cite This Study

Taddei et al. (2011) studied this question.

synapsesocial.com/papers/69d69424e76a53de2732f6c2 https://doi.org/10.1002/path.3000

View Full Paper

Ask AI

Bookmark

Implication

Narrative review details the molecular mechanisms of anoikis and anoikis resistance in human health and disease, highlighting critical therapeutic targets in metastasis, cardiovascular disease,...

Anoikis: an emerging hallmark in health and diseases

Key Points

Discussion

Implication

Cite This Study

Anoikis: an emerging hallmark in health and diseases

Key Points

Discussion

Implication

Cite This Study