Clinical risk analysis reveals increased appendiceal rupture rates after 36 hours of untreated symptoms, highlighting the danger of surgical delays.
Risk of rupture in ensuing 12-hour periods rises to 5% after 36 hours of untreated symptoms. Physicians should be cautious about delaying surgery beyond 36 hours from symptom onset in patients with appendicitis.
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Bickell et al. (2006) studied this question.
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