Key result
Delaying surgical treatment for acute appendicitis beyond 24 hours from symptom onset significantly increased the perforation rate from 3% (<24 hours) to 13% (24-36 hours) and 31% (>36 hours).
Cohort (n=130)
No
Delay beyond 24 hours associated with rising perforation; leaves open optimal timing thresholds for randomized confirmation.
in the morbidity [2][3][4].Appendiceal rupture puts patients at risk for serious sequelae including peritonitis, sepsis and death.Increasing time between symptom onset and treatment may be a risk factor for a ruptured appendix, but little is known about how the risk changes with passing time.Most studies assessing the effect of time between symptom onset and treatment on risk of appendiceal rupture compare ruptured and nonruptured groups [3][4][5].This study aimed to determine the changes in risk of rupture in patients with appendicitis with increasing time from symptom onset to treatment to help guide the swiftness of surgical intervention.
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Koyuncu et al. (2016) conducted a cohort in Acute appendicitis (n=130). Delay in surgical treatment (>24 hours from symptom onset) vs. Surgical treatment within 24 hours of symptom onset was evaluated on Perforation rate (p=<0.001). Delaying surgical treatment for acute appendicitis beyond 24 hours from symptom onset significantly increased the perforation rate from 3% (<24 hours) to 13% (24-36 hours) and 31% (>36 hours).
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