Key result
Delaying appendectomy for acute appendicitis for >12 hours did not significantly affect 30-day overall morbidity (6.1% vs 5.5%; P=0.33) compared to operation within 6 hours.
Why the study?
Does delay to operation increase 30-day morbidity and mortality in adults with acute appendicitis?
Population
32,782 adults with acute appendicitis who underwent an appendectomy
Comparison
Appendectomy performed >6 through 12 hours or… vs Appendectomy performed within 6 hours of…
Design
Cohort
Follow-up
30-day
Authors
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Delay >12h showed no morbidity increase in this cohort; leaves open whether timing affects outcomes or warrants practice change.
Cohort (n=32,782)
Yes
Does delay to operation increase 30-day morbidity and mortality in adults with acute appendicitis?
Absolute Event Rate: 6.1% vs 5.5%
p-value: p=0.33
Delaying appendectomy for acute appendicitis up to or beyond 12 hours does not adversely affect 30-day outcomes, allowing for better allocation of emergency operative resources.
Angela M. Ingraham (2010) conducted a cohort in acute appendicitis (n=32,782). Delay to operation (>12 hours) vs. Operation within 6 hours was evaluated on Thirty-day overall morbidity (p=0.33). Delaying appendectomy for acute appendicitis for >12 hours did not significantly affect 30-day overall morbidity (6.1% vs 5.5%; P=0.33) compared to operation within 6 hours.
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