March 2, 2011Annual Review of Immunology
Natural Innate and Adaptive Immunity to Cancer
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Discussion
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Implication
Review reveals dual host-protective and tumor-promoting roles of immunity across experimental models and clinical cancer, highlighting mechanisms underlying cancer immunoediting.
Key Points
- To synthesize experimental and human clinical evidence examining how innate and adaptive immune components protect against nascent tumors and selectively drive tumor progression.
- Synthesized findings from experimental mouse models of cancer and clinical human oncology data.
- Evaluated specific innate and adaptive immune cell subsets, effector molecules, and signaling pathways contributing to tumor suppression and progression.
- Innate and adaptive immune components function collectively as extrinsic tumor-suppressor mechanisms through cancer immunosurveillance to eliminate early-stage malignant cells.
- Selective immune pressure can facilitate disease progression by shaping tumor immunogenicity, establishing the dual-action paradigm of cancer immunoediting.
- Identified immunoediting pathways establish a mechanistic framework to support the rational design of targeted cancer immunotherapies.
Cite This Study
Vesely et al. (2011) studied this question.