Why the study?
Do chronic increases in myocardial glucose uptake and oxidation cause cardiac dysfunction in mouse models of diet-induced obesity?
Population
Mouse hearts in diet-induced obesity
Design
Preclinical
Authors
Loading...
Hypothesis-generating in obese mouse models; leaves open translation to human metabolic cardiomyopathy.
Do chronic increases in myocardial glucose uptake and oxidation cause cardiac dysfunction in mouse models of diet-induced obesity?
In a mouse model of diet-induced obesity, chronic increases in myocardial glucose uptake and oxidation reduce metabolic flexibility and lead to contractile dysfunction.
Yan et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: