Do chronic increases in myocardial glucose uptake and oxidation cause cardiac dysfunction in mouse models of diet-induced obesity?
In a mouse model of diet-induced obesity, chronic increases in myocardial glucose uptake and oxidation reduce metabolic flexibility and lead to contractile dysfunction.
We have demonstrated that chronic increases in myocardial glucose uptake and oxidation reduce the metabolic flexibility and render the heart susceptible to contractile dysfunction.
Yan et al. (Mon,) studied this question.
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