Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

Yoshitaka Ono; Tomoko Fujii; Koichi Igarashi; Ushio Kikkawa; Kouji Ogita; Yasutomi Nishizuka

doi:10.1093/nar/16.11.5199

January 1, 1988Nucleic Acids ResearchOpen Access

Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

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Key Points

Determine the complete nucleotide and deduced amino acid sequences encoding the alpha and gamma subspecies of protein kinase C in rat brain tissue.
Screened rat brain cDNA libraries using molecular cloning techniques to isolate cDNA clones for distinct protein kinase C subspecies.
Sequenced isolated cDNA clones to characterize the structural variations among the alpha and gamma protein kinase C isoforms.
Identified distinct nucleotide sequences encoding the alpha and gamma subspecies of rat brain protein kinase C.
Demonstrated that protein kinase C exists as a family of structurally related but distinct subspecies within neural tissue.

Implication

Molecular cloning study reveals nucleotide sequences of alpha and gamma protein kinase C subspecies in rat brain, highlighting structural diversity among signaling kinase isoforms.

Abstract

Recent molecular cloning analysis has shown that protein kinase C is a family of multiple subspecies having closely related structures (1-7).

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Cite This Study

Ono et al. (1988) studied this question.

synapsesocial.com/papers/69d72810a98988943d563a1b https://doi.org/10.1093/nar/16.11.5199

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Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

Key Points

Implication

Abstract

Discussion

Cite This Study

Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

Key Points

Implication

Abstract

Discussion

Cite This Study

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