Why the study?
Potential mechanisms of tyrosine kinase inhibitor adverse effects remain unclear, with limited data on early detection, therapeutic modulation, and clinical management.
What are the pathophysiology, mechanisms, and clinical management strategies for TKI-induced adverse effects in cancer patients?
Design
State-of-the-art review
Authors
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May inform CV monitoring during TKI therapy; leaves open optimal management strategies pending prospective trials.
What are the pathophysiology, mechanisms, and clinical management strategies for TKI-induced adverse effects in cancer patients?
This review provides an updated overview of the pathophysiology, risk stratification, and management of TKI-induced cardiovascular and other adverse effects in cancer patients, addressing critical knowledge gaps in cardio-oncology.
Sunder et al. (2023) studied this question.
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