What are the sex differences in clinical, structural, and cellular characteristics at the time of myectomy in patients with hypertrophic cardiomyopathy?
Women with hypertrophic cardiomyopathy present for myectomy at an older age and with more advanced structural, functional, and cellular remodeling compared to men.
Female patients with HCM are older at the time of myectomy and show greater impairment of diastolic function. Furthermore, left ventricular and left atrial remodeling is increased in women when corrected for body surface area. At a cellular level, HCM women showed increased compliant titin and a larger degree of interstitial fibrosis.
Nijenkamp et al. (Thu,) studied this question.