Systematic review uncovers multilevel barriers to clinical research in developing countries, highlighting the necessity of locally led trials to address national healthcare needs.
There were substantial barriers at system, organization and individual level. We propose that to address this problem, instituting a system for wider implementation of local investigator-initiated trials is warranted. These trials are more applicable to local populations because they build on local healthcare knowledge. They are more demand-led, influence policy and responsive to a country's needs because they are driven by a local or national agenda.
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Alemayehu et al. (2018) studied this question.
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