What question did this study set out to answer?

Examine how publication bias distorts clinical research literature and identify systemic factors driving the selective reporting of positive findings.

January 18, 1989JNCI Journal of the National Cancer Institute

Publication Bias and Dissemination of Clinical Research

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Authors

CBColin B. BeggMemorial Sloan Kettering Cancer Center JBJesse A. BerlinRutgers, The State University of New Jersey

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Implication

Narrative review reveals substantial publication bias favoring positive outcomes in clinical literature, highlighting systemic needs for structural and editorial reforms.

Key Points

Examine how publication bias distorts clinical research literature and identify systemic factors driving the selective reporting of positive findings.
Reviewed empiric evidence regarding the preferential publication of statistically significant, positive findings over negative outcomes.
Evaluated systemic influences, including academic promotion pressures, editorial review practices, and conventional statistical significance thresholds.
Empiric data indicate that publication bias introduces substantial distortion into the scientific literature, overrepresenting false-positive outcomes.
Meta-analyses and informal reviews that pool published clinical studies are heavily compromised by the omission of negative results.
Effective mitigation requires restructuring dissemination channels, revising journal editorial criteria, and modifying standard statistical analysis methodologies.

Cite This Study

Begg et al. (1989) studied this question.

synapsesocial.com/papers/69d7698fef4aa71f97f312aa https://doi.org/10.1093/jnci/81.2.107

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Implication

Narrative review reveals substantial publication bias favoring positive outcomes in clinical literature, highlighting systemic needs for structural and editorial reforms.

Publication Bias and Dissemination of Clinical Research

Discussion

Member takes

Implication

Key Points

Cite This Study

Publication Bias and Dissemination of Clinical Research

Discussion

Member takes

Implication

Key Points

Cite This Study

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