What question did this study set out to answer?

To develop a statistical model that quantifies the degree to which publication bias artificially inflates reported treatment efficacy in published clinical literature.

January 1, 1985Statistics in Medicine

A measure to aid in the interpretation of published clinical trials

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Authors

CBColin B. BeggMemorial Sloan Kettering Cancer Center

Discussion

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Implication

Statistical modeling study demonstrates a method to calculate inflated treatment efficacy from publication bias, indicating improved reliability assessments for non-randomized clinical evidence.

Key Points

To develop a statistical model that quantifies the degree to which publication bias artificially inflates reported treatment efficacy in published clinical literature.
Formulated a mathematical model estimating the magnitude of efficacy overestimation based on individual study sample size and concurrent similar studies.
Generated reference tables of bias values to facilitate direct computation and adjustment during the review of published clinical trial data.
Demonstrated that the magnitude of publication bias varies directly as a function of study sample size and the volume of concurrently conducted trials.
Provided tabulated adjustment values to help clinicians assess the reliability of evidence from non-randomized studies when definitive randomized trials are unavailable.
Established that mathematical bias correction aids evidence appraisal but cannot substitute for well-controlled, randomized clinical trials.

Cite This Study

Colin B. Begg (1985) studied this question.

synapsesocial.com/papers/69f7e3596d1e8212df5a2d52 https://doi.org/10.1002/sim.4780040103

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Implication

Statistical modeling study demonstrates a method to calculate inflated treatment efficacy from publication bias, indicating improved reliability assessments for non-randomized clinical evidence.

A measure to aid in the interpretation of published clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

A measure to aid in the interpretation of published clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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