Increased Interleukin-1 and Interleukin-6 Serum Concentrations in Severe Primary Pulmonary Hypertension
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Discussion
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Implication
Case-control study reveals elevated serum interleukin-1 beta and interleukin-6 levels in severe primary pulmonary hypertension, suggesting a pathogenic role for proinflammatory cytokines.
Key Points
- To evaluate the potential role of proinflammatory cytokines by measuring serum levels of IL-1 beta, IL-6, and TNF alpha in patients with severe primary pulmonary hypertension.
- Measured serum concentrations of IL-1 beta, IL-6, and TNF alpha in patients with severe primary pulmonary hypertension referred for lung transplantation (N=29).
- Compared serum cytokine levels against healthy control participants (N=15) and patients with secondary pulmonary hypertension due to chronic obstructive pulmonary disease (N=9).
- Serum IL-1 beta concentrations were significantly increased in severe primary pulmonary hypertension (118 ± 36 pg/ml) compared with healthy controls (3 ± 1 pg/ml, p < 0.001) and COPD-associated pulmonary hypertension (3 ± 1 pg/ml, p < 0.001).
- Serum IL-6 concentrations were significantly elevated in severe primary pulmonary hypertension (66 ± 20 pg/ml) compared with healthy controls (14 ± 6 pg/ml, p < 0.01).
- Serum TNF alpha levels remained within the normal reference range across all evaluated groups.
Cite This Study
Humbert et al. (1995) studied this question.