October 28, 2010Wiley Interdisciplinary Reviews - RNA
Cap and cap‐binding proteins in the control of gene expression
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Discussion
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Implication
Narrative review highlights the central roles of mRNA capping in eukaryotic cells, demonstrating how specialized cap-binding proteins drive processing, export, and translation.
Key Points
- To review the molecular mechanisms of the 5' mRNA cap structure and its associated binding proteins across the life cycle of eukaryotic mRNA.
- Synthesized molecular and biochemical literature regarding co-transcriptional mRNA capping mediated by RNA polymerase II.
- Characterized functional pathways regulated by nuclear and cytoplasmic cap-binding proteins, focusing on nCBC and eIF4E.
- The 5' cap protects transcripts against exonucleolytic degradation and promotes transcription, splicing, polyadenylation, and nuclear export.
- Nuclear cap-binding complex (CBP20/CBP80) coordinates nuclear processing events, while cytoplasmic eIF4E directs efficient protein translation.
Cite This Study
Topisirović et al. (2010) studied this question.