May 1, 1984Biochemistry
Functional characterization of eukaryotic mRNA cap binding protein complex: effects on translation of capped and naturally uncapped RNAs
Population
Extracts prepared from poliovirus-infected or mock-infected HeLa cells
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for CBP in translation; leaves open relevance to cardiovascular mRNA regulation in vivo.
Structured PICO
P
Population
Extracts prepared from poliovirus-infected or mock-infected HeLa cells
I
Intervention
Eukaryotic mRNA cap binding protein (CBP) complex purified by cap analogue affinity chromatography
O
Outcome
Translation of capped and naturally uncapped mRNAssurrogate
The CBP complex facilitates ribosome binding by melting mRNA secondary structure involving 5'-proximal sequences.
Cite This Study
Edery et al. (1984) studied this question.