Why the study?
Different etiologies and release mechanisms may produce different forms of cTn in blood, requiring careful characterization across clinical settings to potentially enable assays differentiating cardiac disease types.
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Design
Review
Characterizing different forms of cardiac troponins in the blood could lead to new immunochemical systems to differentiate types of cardiac disease.
Different etiologies of disease associated with increases of cTn above the 99th percentile and various mechanisms of troponin release from myocardium could result in the appearance of different forms of cTn in blood and provide the first clinical evidence of injury. Additional research is needed for the careful characterization of cTn forms that are present in the blood in different clinical settings. That knowledge may lead to the development of immunochemical systems that would differentiate certain forms of troponins and possibly certain types of cardiac disease.
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Katrukha et al. (2020) studied this question.
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