Why the study?
The timing of onset and underlying mechanisms of anthracycline-induced cardiac atrophy were not well defined, and the relevance to human disease was unclear.
Does doxorubicin exposure cause cardiac atrophy dependent on MuRF1 in mice and humans?
Does doxorubicin exposure cause cardiac atrophy dependent on MuRF1 in mice and humans?
Doxorubicin-induced subacute cardiac atrophy is dependent on the ubiquitin ligase MuRF1, suggesting a potential therapeutic target to preserve cardiac function in cancer patients.
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MuRF1 deletion prevents doxorubicin-induced atrophy in mice; leaves open whether targeting MuRF1 mitigates cardiotoxicity in patients.
Willis et al. (2019) studied this question.
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