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October 10, 2015Journal of the American Heart AssociationOpen Access

Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

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Authors

KAKohei AokiSaitama Medical University YTYasushi TeshimaElectrophysiology HKHidekazu KondoOtsuka (Japan)

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Implication

Indoxyl sulfate may be a therapeutic target for renal dysfunction-induced AF; hypothesis-generating and requires clinical validation.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Aoki et al. (2015) studied this question.

synapsesocial.com/papers/69d80c1238c00da8b4bed86c https://doi.org/10.1161/jaha.115.002023

Topics

Atrial fibrillation Persistent AF management

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Randomized Controlled Trial to Prevent Post-Operative Atrial Fibrillation by Antioxidant Reinforcement2013 · 152 citations
2A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation2005 · 403 citations
3Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation2007 · 525 citations
4Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-.KAPPA.B Pathway2010 · 108 citations
5p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells2012 · 182 citations