Why the study?
Does oral macimorelin provide comparable diagnostic accuracy to the insulin tolerance test for adult growth hormone deficiency?
Does oral macimorelin provide comparable diagnostic accuracy to the insulin tolerance test for adult growth hormone deficiency?
Oral macimorelin is a safe, simple, and accurate diagnostic alternative to the insulin tolerance test for adult growth hormone deficiency.
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May offer simpler alternative to ITT for adult GHD; leaves open need for prospective validation before routine adoption.
Oral macimorelin is a simple, well-tolerated, reproducible, and safe diagnostic test for AGHD with accuracy comparable to that of the ITT. A GH cutoff of 5.1 ng/mL for the macimorelin test provides an excellent balance between sensitivity and specificity.
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Garcia et al. (2018) studied this question.
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