Why the study?
Does good adherence to pharmacologic treatment guidelines improve clinical outcomes in outpatients with HFrEF?
Does good adherence to pharmacologic treatment guidelines improve clinical outcomes in outpatients with HFrEF?
Adherence to guideline-directed medical therapy at ≥50% of target doses is associated with improved short-term clinical outcomes in outpatients with HFrEF.
Answers are grounded in this paper and cite their sources.
May support closer GDMT adherence monitoring in HFrEF outpatients; leaves open causality and need for randomized confirmation.
Good adherence to pharmacologic treatment guidelines for ACEIs, ARBs, BBs, MRAs and ivabradine, with prescription of at least 50% of recommended dosages, was associated with better clinical outcomes during 6-month follow-up. Continuing global educational initiatives are needed to emphasise the importance of guideline recommendations for optimising drug therapy and prescribing evidence-based doses in clinical practice.
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Komajda et al. (2017) studied this question.
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