September 1, 2006AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system

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Structured PICO

Population

Transgenic mice (neuron-specific enolase-AT(1A) overexpressing AT(1A) receptors, and R(+)A(+) overexpressing angiotensinogen and renin) and control (nontransgenic littermates) mice

Intervention

Overexpression of brain renin-angiotensin system components

Comparator

Nontransgenic littermates

Outcome

ACE2 expression and localization in the brainsurrogate

ACE2 is localized to neuronal cytoplasm and regulated by the renin-angiotensin system, suggesting a role in central blood pressure regulation.

Discussion

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Implication

Neuronal ACE2 upregulation may modulate central RAS effects on BP; leaves open human translation and therapeutic relevance.

Cite This Study

Doobay et al. (2006) studied this question.

synapsesocial.com/papers/69d89250d56ca42147d18d2c https://doi.org/10.1152/ajpregu.00292.2006

View Full Paper

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Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system

Structured PICO

Discussion

Implication

Cite This Study

Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider