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April 10, 2026SHILAP Revista de lepidopterologíaOpen Access

Computation and Experimental Approaches to Uncover the Antidiabetic Potential of Insulin Leaf (Tithonia diversifolia) Extract Based on Flavonoid Constituents

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Authors

MMMasniah MasniahESEko SuhartonoFFFujiati Fujiati

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Overview

Experimental and computational methods reveal flavonoids' significant antidiabetic effects in Tithonia diversifolia, suggesting therapeutic potential.

Key Points

  • This research aims to investigate the antidiabetic effects of Tithonia diversifolia through its flavonoid constituents.
  • Extracted Tithonia diversifolia using 90% methanol
  • Analyzed flavonoid content via Liquid Chromatography-Mass Spectrometry (LC-MS)
  • Tested extract for effects on α-amylase enzyme and glycated haemoglobin in vitro
  • Utilized in silico analysis and molecular docking to explore molecular mechanisms
  • Flavonoids like luteolin, genistein, and hispidulin were identified as potent inhibitors of α-amylase
  • IC₅₀ values of flavonoids indicated superior efficacy compared to glibenclamide
  • Docking analysis showed strong interactions between flavonoids and key enzyme residues
  • ADMET predictions suggested favourable absorption and distribution profiles for flavonoids

Cite This Study

Masniah et al. (2026) studied this question.

synapsesocial.com/papers/69d893896c1944d70ce047b1https://doi.org/10.33084/bjop.v9i1.11515
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