Review highlights proactive TLS management strategies in high-risk lung cancer, suggesting improved outcomes.
For patients with high-risk lung cancer (LC), proactive initiation of urate-lowering therapy and hydration along with rasburicase and continued hydration for those who develop tumor lysis syndrome (TLS) may reduce mortality. Further multicenter studies may influence diagnostic criteria, risk assessment, and prophylactic guidelines for TLS to better account for high-risk LC and other solid tumor patients.
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Siddiqui et al. (2026) studied this question.
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