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The aim is to highlight systemic lupus erythematosus as a potential diagnosis in cases of generalized lymphadenopathy.

April 10, 2026CureusOpen Access

A Case of Systemic Lupus Erythematosus Initially Presenting With Generalized Lymphadenopathy: A Diagnostic Challenge

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The aim is to highlight systemic lupus erythematosus as a potential diagnosis in cases of generalized lymphadenopathy.
Case report of a 47-year-old man with symptoms of fever and lymphadenopathy
Extensive diagnostic workup to exclude infectious and malignant causes
Lupus-specific serological testing to confirm diagnosis
Patient demonstrated evolving clinical symptoms leading to diagnosis of SLE
Fulfilled ACR/EULAR classification criteria for SLE based on immunological findings
Treatment with corticosteroids and immunosuppressive therapy resulted in significant improvement

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Case report reveals systemic lupus erythematosus as a diagnostic challenge in patients with lymphadenopathy, implying a need for careful evaluation.

Vázquez-Meraz et al. (2026) studied this question.

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Case report reveals systemic lupus erythematosus as a diagnostic challenge in patients with lymphadenopathy, implying a need for careful evaluation.