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To report a rare case of new-onset systemic lupus erythematosus mimicking lymphoma following a viral infection.

July 29, 2026Discover MedicineOpen Access

A case of post-viral lymphoma-like syndrome unmasking systemic lupus erythematosus

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To report a rare case of new-onset systemic lupus erythematosus mimicking lymphoma following a viral infection.
Patient presented with lymphadenopathy, arthralgias, and fever post-influenza A.
PET-CT indicated possible lymphoma; lymph node biopsy performed.
Serologic tests showed positive autoimmune markers including ANA and anti-dsDNA.
Lymph node biopsy indicated acute lymphadenitis, ruling out malignancy.
Confirmed systemic lupus erythematosus diagnosis after development of malar rash.
Initiation of hydroxychloroquine led to sustained clinical response.

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Case report details how a woman’s systemic lupus erythematosus mimicked lymphoma post-influenza infection, suggesting diagnostic caution.

Bell et al. (2026) studied this question.

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Case report details how a woman’s systemic lupus erythematosus mimicked lymphoma post-influenza infection, suggesting diagnostic caution.