This proof-of-concept study explores serum endocan's role as a biomarker of neuronal injury in a rodent model of SAH, suggesting its potential for further research.
Key Points
The study aims to characterize serum endocan levels following subarachnoid hemorrhage and their relationship with neuronal injury.
Experimental study using male Sprague–Dawley rats assigned to Sham and SAH groups
Induction of SAH via cisterna magna injection of autologous blood
Timed collection of serum samples at 0, 6, 24, and 48 hours
Measurement of endocan concentrations using enzyme-linked immunosorbent assay
Statistical analyses included t-tests, repeated measures ANOVA, and correlation tests
Endocan levels significantly increased in the SAH group at 6, 24, and 48 hours compared to Sham
Levels progressively rose over time within the SAH group
A positive correlation was found between endocan levels at 48 hours and hippocampal neuronal degeneration scores