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April 10, 2026Drug Design Development and TherapyOpen Access

Bioactive Flavonoids from Scutellaria baicalensis in Non-Small Cell Lung Cancer: Mechanistic Insights and Emerging Translational Perspectives

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Authors

JYJiaqian YuanZhejiang Chinese Medical UniversityZWZhen WangZhejiang Chinese Medical University

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Overview

This review highlights pharmacological mechanisms and drug delivery of Scutellaria baicalensis to combat NSCLC, suggesting promising translational potential.

Key Points

  • The review aims to summarize the pharmacological properties and mechanisms of bioactive flavonoids from Scutellaria baicalensis in treating non-small cell lung cancer.
  • Systematic review of current literature from PubMed, Web of Science, and Embase.
  • Analysis of pharmacokinetic characteristics and toxicity profiles using ADMETlab 2.0.
  • Evaluation of anti-NSCLC effects through preclinical studies in vitro and in vivo.
  • Flavonoids from Scutellaria baicalensis exhibit anti-NSCLC effects through multiple mechanisms.
  • Mechanisms include inhibition of tumor proliferation, apoptosis, autophagy, and modulation of the tumor immune microenvironment.
  • Nanocarrier-based systems improve the bioavailability and targeting of these compounds.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69d8940c6c1944d70ce050b8https://doi.org/10.2147/dddt.s591381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Scutellaria baicalensis in cancer therapy: multidimensional mechanisms and therapeutic potential2025
  2. 2A Review of the Research Progress on the Anticancer Mechanisms of the Active Components Baicalin and Baicalein of Scutellaria baicalensis in Digestive System Tumors2026
  3. 3Network Pharmacology and Metabolomics to Uncover the Multi-Target Anti-Non-Small Cell Lung Cancer Mechanism of Baicalin Mediated by Purine Metabolism2026
  4. 4Research Progress of <i>Scutellaria baicalensis</i> in the Treatment of Gastrointestinal Cancer2024 · 12 citations
  5. 5Promising Anti‐Cancer Effects and Mechanisms of Baicalin and Baicalein in the Treatment of Oral Cancer: A Comprehensive Review2026