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This review summarizes the pharmacological activities and mechanisms of baicalin and baicalein in treating oral squamous cell carcinoma (OSCC).

June 1, 2026Oral DiseasesOpen Access

Promising Anti‐Cancer Effects and Mechanisms of Baicalin and Baicalein in the Treatment of Oral Cancer: A Comprehensive Review

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Comprehensive review highlights anti-cancer mechanisms in oral squamous cell carcinoma with potential applications.

This review summarizes the pharmacological activities and mechanisms of baicalin and baicalein in treating oral squamous cell carcinoma (OSCC).
Conducted comprehensive literature search using multiple electronic databases.
Analyzed mechanisms of action and pharmacological effects of baicalin and baicalein.
Identified challenges such as solubility and bioavailability affecting clinical translation.
Baicalin and baicalein induce apoptosis in OSCC cells, mediated by Bax/Bcl-2 modulation and caspase-3 activation.
Show reduced metastatic activity by increasing E-cadherin and decreasing vimentin, MMP2, and MMP9 levels.
Confirmed good safety profile with minimal adverse effects at therapeutic doses.

Karbasi et al. (2026) studied this question.

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