Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In Vitro Evidence

Shilin Zeng; Hongying Wang; Wanying Yang; Yuzhou Zeng; Weihui Shentu; Yi Fang

doi:10.1111/jog.70263

April 1, 2026Journal of obstetrics and gynaecology research

Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In Vitro Evidence

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Key Points

This research aims to explore the role of chemerin in fetal endothelial dysfunction linked to gestational diabetes mellitus (GDM).
Analyzed circulating chemerin levels in pregnancies with GDM.
Studied mRNA and protein expression to assess post-transcriptional regulation.
Investigated the utility of cord blood chemerin as a biomarker for vascular injury.
Evaluated fetal arterial pulse velocity (APV) as a non-invasive assessment tool.
Found elevated levels of chemerin in GDM patients associated with endothelial dysfunction.
Observed discordance between mRNA and protein levels indicating complex regulatory mechanisms.
Identified cord blood chemerin as a potential biomarker for assessing fetal vascular injury.
Highlighted the need for studies on CMKLR1 antagonists to explore therapeutic options.

Implication

Bioinformatics integrates findings on chemerin's impact on endothelial dysfunction in gestational diabetes, suggesting its clinical relevance.

Abstract

Elevated circulating chemerin is associated with fetal endothelial dysfunction in GDM. Discordant mRNA/protein levels suggest post-transcriptional regulation. Cord blood chemerin may serve as a biomarker of fetal vascular injury, while fetal APV offers a non-invasive clinical tool. CMKLR1 antagonist studies are needed to establish therapeutic potential.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69d8955f6c1944d70ce065a2 https://doi.org/10.1111/jog.70263

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Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In Vitro Evidence

Key Points

Implication

Abstract

Discussion

Cite This Study

Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In Vitro Evidence

Key Points

Implication

Abstract

Discussion

Cite This Study

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