What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Diabetes mellitus (n=100). Intervention: Diabetes mellitus vs. Nondiabetic individuals. Primary outcome: PT, INR, and aPTT values.

What question did this study set out to answer?

To compare prothrombin time, international normalized ratio, and activated partial thromboplastin time between diabetic and nondiabetic individuals and assess their relationship with glycated hemoglobin levels.

April 10, 2026Annals of African Medicine

Assessing Prothrombin Time and Activated Partial Thromboplastin Time Variations with Glycemic Status: A Cross-sectional Comparative Study

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Key result

, no parentheticals.

n=100

Why the study?

Does glycemic status alter coagulation parameters (PT, INR, aPTT) in diabetic patients compared to nondiabetics?

Population

Diabetic individuals

Comparison

Poor glycemic control vs other glycemic status

Design

Cross-sectional comparative study

Authors

MDMansha DuaVinayaka Missions University SSS. D. Baby SruthiVinayaka Missions University SBS. R. Ranga BashyamVinayaka Missions University

Discussion

Member takes

Implication

May warrant routine coagulation screening in poorly controlled diabetes; extends low-certainty evidence but should not yet change practice.

Key Points

To compare prothrombin time, international normalized ratio, and activated partial thromboplastin time between diabetic and nondiabetic individuals and assess their relationship with glycated hemoglobin levels.
Conducted a cross-sectional comparative study involving 100 subjects aged 18–60 years stratified into diabetic and nondiabetic cohorts at a tertiary care hospital.
Excluded individuals on anticoagulant therapy or with pre-existing coagulation disorders, sepsis, active malignancy, or type 1 diabetes.
Measured plasma prothrombin time, international normalized ratio, and activated partial thromboplastin time using turbidometric assays alongside HbA1c testing.
Diabetic participants exhibited significantly shortened activated partial thromboplastin time and mildly prolonged prothrombin time and international normalized ratio compared to nondiabetic controls.
Glycated hemoglobin correlated negatively with activated partial thromboplastin time and positively with prothrombin time and international normalized ratio, with changes most pronounced at HbA1c levels exceeding 8%.

Study Design

Type

Cross-Sectional (n=100)

Multicenter

Structured PICO

Does glycemic status alter coagulation parameters (PT, INR, aPTT) in diabetic patients compared to nondiabetics?

Population

100 subjects aged 18-60 years, categorized into diabetics and nondiabetics, excluding those on anticoagulants, with coagulation disorders, sepsis, malignancy, or type 1 diabetes.

Exposure

Type 2 diabetes mellitus with varying glycemic status (measured by HbA1c)

Comparator

Nondiabetic individuals

Outcome

Prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)surrogate

Poor glycemic control in diabetic patients is associated with measurable alterations in coagulation parameters (shortened aPTT and prolonged PT/INR), indicating a prothrombotic state.

Cite This Study

Dua et al. (2026) conducted a cross-sectional in Diabetes mellitus (n=100). Diabetes mellitus vs. Nondiabetic individuals was evaluated on PT, INR, and aPTT values. Diabetes mellitus was associated with significantly shortened aPTT and mildly prolonged PT/INR compared to nondiabetics, with trends more pronounced in subjects with HbA1c >8%.

synapsesocial.com/papers/69d8955f6c1944d70ce06662 https://doi.org/10.4103/aam.aam_824_25

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Implication

May warrant routine coagulation screening in poorly controlled diabetes; extends low-certainty evidence but should not yet change practice.

Assessing Prothrombin Time and Activated Partial Thromboplastin Time Variations with Glycemic Status: A Cross-sectional Comparative Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Assessing Prothrombin Time and Activated Partial Thromboplastin Time Variations with Glycemic Status: A Cross-sectional Comparative Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider