November 1, 1980Diabetes Care
Plasma Antithrombin III and Thrombin Generation Time: Correlation with Hemoglobin A1 and Fasting Serum Glucose in Young Diabetic Women
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Discussion
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Implication
Cross-sectional study demonstrates reduced antithrombin III and accelerated clotting in young diabetic women, suggesting tight glycemic control may prevent hypercoagulability.
Key Points
- To examine the relationship between glycemic control and hypercoagulability markers in young nonpregnant and pregnant women with insulin-dependent diabetes.
- Evaluated 38 female participants across four groups: 10 young healthy controls, 10 young insulin-dependent diabetic subjects, 10 pregnant nondiabetic subjects, and 8 first-trimester pregnant insulin-dependent diabetic subjects.
- Measured coagulability indices (thrombin generation time [TGT], antithrombin III [AT III], and activated partial thromboplastin time) alongside glycemic control markers (serial fasting serum glucose [FG] and hemoglobin A1 [HbA1]).
- AT III levels were significantly higher in controls (99.7 ± 2.7%) than in nondiabetic pregnant (83.2 ± 3.8%), diabetic (79.5 ± 2.5%), and pregnant diabetic subjects (76.2 ± 4.4%; P < 0.01).
- TGT was significantly shorter in nonpregnant diabetic, pregnant nondiabetic, and pregnant diabetic groups compared to controls (P < 0.01).
- In young diabetic subjects, AT III negatively correlated with FG (r = -0.76, P < 0.01) and HbA1 (r = -0.79, P < 0.01), while HbA1 positively correlated with FG in nonpregnant (r = 0.88, P < 0.005) and pregnant diabetic subjects (r = 0.74, P < 0.05).
Cite This Study
Sowers et al. (1980) studied this question.