March 1, 1987Diabetes
Induced Hyperglycemia Alters Antithrombin III Activity but not its Plasma Concentration in Healthy Normal Subjects
Key result
Induced hyperglycemia decreases ATIII biologic activity without altering plasma concentration, an effect prevented by heparin.
Why the study?
The effects of induced hyperglycemia on antithrombin III biologic activity and plasma concentration in normal subjects were not well characterized.
Does induced hyperglycemia alter antithrombin III activity and plasma concentration in healthy normal subjects?
Population
Healthy normal subjects
Comparison
Induced hyperglycemia with or without heparin infusion vs basal glycemia
Design
Other study design
Authors
Discussion
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Member takes
Implication
May link hyperglycemia to antithrombin dysfunction in diabetes; leaves open heparin's in vivo role.
Structured PICO
Does induced hyperglycemia alter antithrombin III activity and plasma concentration in healthy normal subjects?
P
Population
Healthy normal subjects undergoing induced hyperglycemia to assess antithrombin III activity.
I
Intervention
Induced hyperglycemia (with or without heparin infusion)
C
Comparator
Basal glycemia (normoglycemia)
O
Outcome
Antithrombin III (ATIII) biologic activity and plasma concentrationsurrogate
Hyperglycemia directly alters antithrombin III biologic activity, which can be preserved by heparin, suggesting a potential mechanism for thrombotic complications in diabetes.
Cite This Study
Ceriello et al. (1987) studied Healthy Normal Subjects. Induced hyperglycemia and heparin infusion vs. Basal glycemia was evaluated on Antithrombin III (ATIII) biologic activity and plasma concentration. Induced hyperglycemia decreased antithrombin III biologic activity without altering its plasma concentration, an effect that was significantly preserved by heparin infusion.